Friday 21 February 2020

Different Types of Proteoglycan Sulfates


  • Chondroitin sulfates are the most prominent proteoglycans in cartilage and bone.
  • Keratin sulfates are most prominent in the cornea (type I) and loose connective tissue (type II).
  • Heparin sulfate is present mostly in basement membranes, cell surfaces, and ECM.
  • Dermatan sulfate is widely distributed in skin and vascular tissue.
  • Hyaluronic acid is the most unique GAG in that it consists of an unbranched chain of repeating disaccharide units. It does not form a proteoglycan and does not contain sulfur. It is widely distributed in ECM, vitreous humor, synovial fluid, and loose connective tissue.

Q) Which of the following is the most abundant glycosaminoglycan?

A. Keratansulfate
B. Heparansulfate
C. Chondroitin sulfate 
D. Dermatan sulfate 
E. Hyaluronic acid
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Different Types of Proteoglycan Sulfates

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